D Dimer Detection Kit

D-Dimer Detection Kit (Fluorescence Immunoassay)

Application

It is suitable for quantitative determination of D-dimer (D-Dimer) in human plasma or whole blood in vitro.

Package

1 test/kit, 5 tests/kit, 10tests/kit,25 tests/kit, 50 tests/kit.

Glossary

There is fibrin in the blood, and fibrin is activated and hydrolyzed to produce specific degradation products called "fibrin degradation products. D-dimer is the simplest fibrin degradation product, and the level of D-dimer increases. A high level indicates that there is a hypercoagulable state and secondary hyperfibrinolysis in the body. Therefore, the mass concentration of D-dimer is of great significance for the diagnosis, efficacy evaluation and prognosis judgment of thrombotic diseases.

Clinical Significance

1. Exclusion diagnosis of venous thromboembolism (VTE)

2. Risk stratification and prognostic assessment of ACS patients

3. Diagnosis of Disseminated Intravascular Coagulation (DIC)

4. Prognosis of surgical patients

5. Diagnosis and detection of hypercoagulable state in pregnancy-induced hypertension syndrome

6. Auxiliary diagnosis of cerebral infarction and ACS

Main components:

The kit consists of D-Dimer detection reagent card, detection buffer, ID card, instruction manual, desiccant, and aluminum foil bag.

D-dimer detection reagent card: D-dimer monoclonal antibody (0.1-2 mg/mL), anti-chicken IgY polyclonal antibody (0.1-2 mg/mL), time-resolved fluorescent microsphere labeling D-dimer monoclonal antibody (0.1-2 mg/mL) and time-resolved fluorescent microsphere-labeled chicken IgY antibody (0.1-2 mg/mL).

Detection buffer: 0.01M phosphate buffer, pH=7.4±0.5, Proclin 300 0.3g/L.

D-Dimer (D-Dimer)

 

D-dimer is a specific degradation product produced by plasmin hydrolysis after fibrin monomer is cross-linked by activating factor XIII. It is a specific marker of fibrinolysis process. D-dimers are derived from cross-linked fibrin clots lysed by plasmin. English abbreviation D-Dimer.

D-dimer mainly reflects fibrinolytic function. Increased or positive seen in secondary hyperfibrinolysis, such as hypercoagulable state, disseminated intravascular coagulation, renal disease, organ transplant rejection, thrombolytic therapy, etc. 

 

      As long as there is active thrombosis and fibrinolytic activity in the body's blood vessels, D-dimer will increase. Myocardial infarction, cerebral infarction, pulmonary embolism, venous thrombosis, surgery, tumor, disseminated intravascular coagulation, infection and tissue necrosis can lead to elevated D-dimer. Especially for the elderly and hospitalized patients, due to bacteremia and other diseases, it is easy to cause abnormal blood coagulation and lead to increased D-dimer. The increased level of D-dimer indicates the existence of hypercoagulable state and secondary hyperfibrinolysis in the body. Therefore, the concentration of D-dimer is of great significance for the diagnosis, efficacy evaluation and prognosis judgment of thrombotic diseases.

 

      The dimer can be used as an observation index for the effect of thrombolytic therapy. In recent years, with the continuous deepening of clinical research on D-dimer, D-dimer detection has penetrated into the fields of cardiovascular disease, DIC, anticoagulation therapy, etc., and its clinical application has become more and more extensive. It plays an extremely important clinical value in the diagnosis, treatment, prognosis and prognosis of malignant tumors, pregnancy-induced hypertension, diabetic vascular disease and other diseases, and has now become the "gold standard" for the clinical diagnosis of deep vein thrombosis and pulmonary embolism.

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